Protein Kinase A (PKA) is a crucial enzyme that plays a significant role in cellular signaling by phosphorylating specific serine and threonine residues on target proteins. It is activated by cyclic AMP (cAMP), a secondary messenger that mediates hormonal responses, particularly those associated with glucagon and epinephrine. PKA's activation leads to a cascade of metabolic processes, influencing various pathways such as glycogen breakdown and lipid metabolism, thereby integrating hormonal control of metabolism effectively.
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