TH2 cells

Definition

TH2 cells, also known as T-helper 2 cells, are a subset of CD4+ T cells that play a crucial role in humoral immunity by promoting B cell activation and antibody production. They primarily secrete cytokines like IL-4, IL-5, IL-10, and IL-13.

5 Must Know Facts For Your Next Test

1. TH2 cells are essential for the activation of B lymphocytes and the production of antibodies.
2. They secrete cytokines such as IL-4, IL-5, IL-10, and IL-13 which help in the differentiation of B cells into plasma cells.
3. TH2 responses are typically involved in defense against extracellular pathogens like parasites and allergens.
4. An imbalance favoring TH2 responses can contribute to allergic reactions and asthma.
5. The differentiation from naïve CD4+ T cells to TH2 cells is promoted by the presence of the cytokine IL-4.

Review Questions

• What type of immunity do TH2 cells primarily support?
• Name two key cytokines secreted by TH2 cells.
• How does an overactive TH2 response impact human health?

Related terms

CD4+ T Cells: A type of immune cell that plays a significant role in orchestrating the immune response.

Cytokines:

Small proteins released by cells that have a specific effect on interactions and communications between cells.

B Lymphocytes (B Cells): White blood cells that produce antibodies and are critical for humoral immunity.