TH17 cells

Definition

TH17 cells are a subset of CD4+ T helper cells that produce the cytokine IL-17 and play a crucial role in defending against extracellular pathogens and contributing to inflammatory responses.

5 Must Know Facts For Your Next Test

1. TH17 cells are essential for mucosal immunity, particularly in the gut.
2. They are involved in the pathogenesis of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
3. IL-23 is important for the maintenance and expansion of TH17 cells.
4. Differentiation into TH17 cells requires the cytokines IL-6, TGF-β, and IL-1β.
5. TH17 cells can recruit neutrophils to sites of infection.

Review Questions

• What cytokines are required for the differentiation of TH17 cells?
• How do TH17 cells contribute to autoimmune diseases?
• What is the role of IL-23 in relation to TH17 cells?

Related terms

CD4+ T Cells: A type of immune cell that assists other white blood cells in immunologic processes.

Cytokine IL-17: A pro-inflammatory cytokine produced by TH17 cells involved in host defense and autoimmunity.

TGF-β (Transforming Growth Factor-beta): A multifunctional cytokine that plays a crucial role in immune regulation and differentiation of various T cell subsets including TH17.