PANDAS

Definition

PANDAS, or Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, is a condition where a child's immune system reacts to a streptococcal (strep) infection, leading to the sudden onset of neuropsychiatric symptoms. This term is particularly relevant in the context of Obsessive-Compulsive and Related Disorders, as PANDAS can be a trigger for the development or exacerbation of these types of disorders in children.

5 Must Know Facts For Your Next Test

1. PANDAS is believed to be triggered by an autoimmune response to a streptococcal infection, where the body's immune system attacks the brain, leading to the sudden onset of neuropsychiatric symptoms.
2. The most common symptoms of PANDAS include obsessive-compulsive behaviors, tics, anxiety, emotional lability, and deterioration in school performance.
3. PANDAS is typically diagnosed in children between the ages of 3 and 12, with the average age of onset being around 6 or 7 years old.
4. Treatment for PANDAS often involves antibiotics to treat the underlying streptococcal infection, as well as cognitive-behavioral therapy and, in some cases, medication to manage the neuropsychiatric symptoms.
5. Early recognition and treatment of PANDAS is crucial, as the condition can have a significant impact on a child's social, emotional, and academic functioning if left untreated.

Review Questions

• Explain the connection between streptococcal infections and the development of PANDAS.
  • PANDAS is believed to be triggered by an autoimmune response to a streptococcal (strep) infection. When a child's immune system encounters the streptococcal bacteria, it can mistakenly attack the brain, leading to the sudden onset of neuropsychiatric symptoms, such as obsessive-compulsive behaviors, tics, and anxiety. This autoimmune reaction is thought to be the underlying cause of PANDAS, as the body's own immune system attacks healthy brain tissue, resulting in the characteristic symptoms of the disorder.
• Describe the typical presentation and timeline of PANDAS in children.
  • PANDAS typically affects children between the ages of 3 and 12, with the average age of onset being around 6 or 7 years old. The condition is characterized by the sudden onset of neuropsychiatric symptoms, including obsessive-compulsive behaviors, tics, anxiety, emotional lability, and deterioration in school performance. These symptoms often appear abruptly, following a streptococcal infection, and can wax and wane over time, with periods of exacerbation and remission. Early recognition and treatment of PANDAS is crucial, as the condition can have a significant impact on a child's social, emotional, and academic functioning if left untreated.
• Evaluate the role of treatment in managing PANDAS and its associated symptoms.
  • The treatment of PANDAS typically involves a multi-pronged approach. First, antibiotics are often prescribed to treat the underlying streptococcal infection, as this is believed to be the trigger for the autoimmune response. Additionally, cognitive-behavioral therapy can be used to help the child manage their obsessive-compulsive behaviors and other neuropsychiatric symptoms. In some cases, medication may also be necessary to address issues like anxiety or mood changes. Early and comprehensive treatment is crucial, as it can help mitigate the impact of PANDAS on the child's social, emotional, and academic functioning. By addressing both the underlying cause (the streptococcal infection) and the resulting symptoms, healthcare providers can work to effectively manage PANDAS and support the child's overall well-being.

Related terms

Streptococcal Infection: A bacterial infection caused by streptococcus bacteria, which can lead to conditions like strep throat, scarlet fever, and rheumatic fever.

Autoimmune Disorder: A condition where the body's immune system mistakenly attacks its own healthy cells and tissues, leading to a variety of symptoms.

Neuropsychiatric Symptoms: Symptoms that affect both the brain and mental health, such as obsessive-compulsive behaviors, tics, anxiety, and mood changes.