The Treaty of New Echota was an 1835 agreement between the U.S. government and a faction of the Cherokee Nation, which ultimately led to the forced removal of the Cherokee people from their ancestral lands in the Southeast to designated territory west of the Mississippi River. This treaty, signed by a small group of Cherokee leaders without the consent of the majority, is significant as it highlights the complexities of Native American treaties and the implications of such agreements in U.S. history.