The Battle of Tippecanoe was a significant confrontation between American forces and Native American warriors led by Tecumseh and his brother Tenskwatawa, known as the Prophet, that took place in November 1811. This battle marked a crucial moment in the conflict between Native Americans and European settlers in the early 19th century, setting the stage for further confrontations during the War of 1812 and highlighting the struggle for Native sovereignty and resistance against American expansion.