A 2x2 determinant is a mathematical expression that represents the area scaling factor of a linear transformation in a two-dimensional space. It is calculated from a 2x2 matrix using the formula $$det(A) = ad - bc$$ for a matrix \( A = \begin{pmatrix} a & b \\ c & d \end{pmatrix} \), where 'a', 'b', 'c', and 'd' are the elements of the matrix. Understanding 2x2 determinants is crucial for solving systems of equations, particularly when applying Cramer's Rule, which utilizes determinants to find unique solutions to linear equations.