The deerskin trade was a significant economic exchange in the colonial Southeast, where deerskins were traded primarily between Native American tribes and European settlers. This trade provided valuable resources for both parties, as it allowed Native Americans to obtain goods such as weapons and tools while supplying Europeans with a key commodity for the burgeoning textile industry in Europe. The interactions surrounding this trade shaped relationships between the Cherokee and Creek societies and European colonists, influencing social structures, economies, and power dynamics in the region.