European exploration of the Americas began in the late 15th century, driven by a desire for new trade routes and resources. Explorers like Columbus, Ponce de León, and de Soto ventured into the New World, encountering diverse Native American cultures and establishing early settlements. The Age of Exploration was motivated by economic, religious, and political factors. It led to the Columbian Exchange, cultural clashes, and the beginnings of European colonization in the Americas, setting the stage for centuries of interaction and conflict between Old and New World societies.