key term - Exoenzyme S

Definition

Exoenzyme S is a virulence factor produced by Pseudomonas aeruginosa. It disrupts host cell function by ADP-ribosylation of various cellular proteins.

5 Must Know Facts For Your Next Test

1. Exoenzyme S is secreted via the Type III secretion system of Pseudomonas aeruginosa.
2. It plays a significant role in bacterial infections, particularly affecting the skin and eyes.
3. Exoenzyme S contributes to tissue damage and immune evasion.
4. It can modify host cell signaling pathways, leading to disrupted cellular functions.
5. Exoenzyme S has been implicated in chronic infections, such as those seen in cystic fibrosis patients.

Review Questions

Related terms

Type III Secretion System:

A needle-like protein apparatus used by some bacteria to inject toxins into host cells.

Virulence Factor: Molecules produced by pathogens that enhance their ability to cause disease.

ADP-Ribosylation: A chemical modification where an ADP-ribose moiety is transferred onto a target protein, altering its function.