Protection Against Self-Incrimination is a legal principle that prevents individuals from being compelled to testify against themselves in criminal cases. This right is rooted in the Fifth Amendment of the U.S. Constitution, which safeguards against self-incrimination and ensures that individuals cannot be forced to provide evidence that may be used to convict them. This principle is vital for maintaining fairness in the legal system, promoting the idea that the burden of proof lies with the prosecution.