Physiology of Motivated Behaviors

💪Physiology of Motivated Behaviors Unit 5 – Hunger and Eating Behaviors

Hunger and eating behaviors are complex processes regulated by intricate interactions between the brain, hormones, and digestive system. These mechanisms involve key hormones like ghrelin and leptin, which influence appetite and satiety, as well as neural circuits in the hypothalamus and other brain regions. Eating behaviors are influenced by both physiological and psychological factors. While homeostatic eating maintains energy balance, hedonic eating is driven by pleasure. Environmental and social influences, such as food availability and cultural norms, also play significant roles in shaping eating habits and potential disorders.

Key Concepts and Definitions

  • Hunger refers to the physiological drive to consume food and is regulated by complex interactions between the brain, hormones, and the digestive system
  • Satiety is the feeling of fullness and satisfaction after eating that suppresses further hunger
  • Appetite encompasses the psychological desire to eat, which can be influenced by various factors such as emotions, social cues, and food palatability
  • Ghrelin, known as the "hunger hormone," is produced by the stomach and stimulates appetite by acting on the hypothalamus
    • Ghrelin levels increase before meals and decrease after eating
  • Leptin, the "satiety hormone," is released by adipose tissue and signals the brain to reduce food intake and increase energy expenditure
  • Homeostatic eating involves consuming food to maintain energy balance and is regulated by physiological hunger and satiety signals
  • Hedonic eating, also known as "pleasure-driven eating," is motivated by the rewarding aspects of food, such as taste, smell, and texture, rather than physiological needs

Physiological Mechanisms of Hunger

  • The hypothalamus plays a central role in regulating hunger and satiety by integrating signals from the digestive system, hormones, and other brain regions
  • The arcuate nucleus (ARC) of the hypothalamus contains two key populations of neurons: appetite-stimulating (orexigenic) AgRP/NPY neurons and appetite-suppressing (anorexigenic) POMC/CART neurons
  • Ghrelin activates AgRP/NPY neurons, increasing appetite, while leptin inhibits these neurons and activates POMC/CART neurons, reducing appetite
  • The stomach's stretching during eating triggers the release of the hormone cholecystokinin (CCK), which stimulates vagal afferents to signal satiety to the brain
  • Blood glucose levels influence hunger; low levels stimulate hunger, while high levels promote satiety
    • The brain, particularly the hypothalamus, monitors glucose levels and adjusts food intake accordingly
  • Insulin, released by the pancreas in response to rising blood glucose, acts on the hypothalamus to reduce appetite and increase energy expenditure
  • Peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) are released by the intestines after eating and contribute to feelings of satiety

Neural Circuits Involved in Eating

  • The hypothalamus integrates peripheral signals and communicates with other brain regions to regulate eating behavior
  • The lateral hypothalamus (LH) contains orexin neurons that promote appetite and food-seeking behavior
  • The ventromedial hypothalamus (VMH) is involved in satiety and energy balance regulation
  • The paraventricular nucleus (PVN) of the hypothalamus receives input from the ARC and regulates food intake and energy expenditure
  • The mesolimbic dopamine system, which includes the ventral tegmental area (VTA) and nucleus accumbens (NAc), is involved in the rewarding aspects of eating
    • Palatable foods activate this system, potentially leading to overconsumption
  • The prefrontal cortex (PFC) is involved in decision-making and self-control related to eating behavior
  • The amygdala processes emotional responses to food and plays a role in learned food preferences and aversions
  • The hippocampus is involved in forming memories related to food experiences and can influence future eating behavior

Hormonal Regulation of Appetite

  • Ghrelin, produced by the stomach, stimulates hunger by activating AgRP/NPY neurons in the hypothalamus and promoting food-seeking behavior
  • Leptin, secreted by adipose tissue, suppresses appetite by inhibiting AgRP/NPY neurons and activating POMC/CART neurons in the hypothalamus
    • Leptin resistance can occur in obesity, leading to reduced satiety signaling despite high leptin levels
  • Insulin, released by the pancreas, acts on the hypothalamus to reduce appetite and increase energy expenditure
  • Cholecystokinin (CCK), secreted by the intestines in response to food intake, stimulates vagal afferents to signal satiety to the brain
  • Peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), released by the intestines after eating, promote feelings of fullness and reduce appetite
  • Cortisol, a stress hormone, can stimulate appetite and lead to increased food intake, particularly of high-calorie, palatable foods
  • Sex hormones, such as estrogen and testosterone, can influence appetite and eating behavior
    • Estrogen tends to have an appetite-suppressing effect, while testosterone may increase appetite

Psychological Factors in Eating Behavior

  • Emotional eating involves consuming food in response to negative emotions, such as stress, anxiety, or sadness, rather than physiological hunger
  • Boredom eating occurs when individuals eat to alleviate feelings of boredom or to seek stimulation
  • Restrained eating is characterized by intentional efforts to restrict food intake to control body weight, which can lead to disinhibited eating when self-control is undermined
  • Disinhibited eating involves a loss of control over food intake, often in response to external cues or emotional triggers
  • Food cravings are intense desires for specific foods that can be influenced by various factors, such as stress, hormonal changes, and sensory cues
  • Learned food preferences and aversions can develop through classical conditioning, where food is associated with positive or negative experiences
  • Mindful eating involves paying attention to the sensory aspects of food and eating experiences without judgment, which can help regulate food intake and promote a healthy relationship with food

Disorders of Eating and Appetite

  • Anorexia nervosa is characterized by severe restriction of food intake, an intense fear of gaining weight, and a distorted body image
  • Bulimia nervosa involves episodes of binge eating followed by compensatory behaviors, such as self-induced vomiting, excessive exercise, or misuse of laxatives or diuretics
  • Binge eating disorder is characterized by recurrent episodes of consuming large amounts of food in a short period, accompanied by a sense of loss of control and feelings of distress
  • Night eating syndrome involves consuming a significant portion of daily caloric intake after the evening meal or during nighttime awakenings
  • Pica is a condition in which individuals crave and consume non-food substances, such as clay, chalk, or ice
  • Avoidant/restrictive food intake disorder (ARFID) is characterized by a persistent failure to meet appropriate nutritional or energy needs due to a lack of interest in food, sensory sensitivities, or fear of adverse consequences
  • Obesity is a complex disorder characterized by excessive body fat accumulation, which can result from a combination of genetic, environmental, and behavioral factors

Environmental and Social Influences

  • Food availability and accessibility can significantly impact eating behavior, with greater exposure to high-calorie, palatable foods leading to increased consumption
  • Portion sizes have increased over time, contributing to overconsumption and the prevalence of obesity
  • Social norms and cultural practices influence eating habits, such as the types of foods consumed, meal timing, and portion sizes
  • Family and peer influences can shape eating behaviors through modeling, encouragement, or pressure to eat certain foods or quantities
  • Food marketing and advertising can influence food choices and consumption, particularly for highly processed, high-calorie foods
  • Socioeconomic status can impact access to healthy food options and nutrition education, with lower-income populations often facing greater barriers to maintaining a balanced diet
  • The built environment, including the presence of food outlets, parks, and walkable neighborhoods, can influence eating habits and physical activity levels

Practical Applications and Current Research

  • Mindfulness-based interventions, such as mindful eating training, can help individuals develop a healthier relationship with food and improve eating behaviors
  • Cognitive-behavioral therapy (CBT) can be effective in treating eating disorders by addressing underlying psychological factors and promoting healthy coping strategies
  • Pharmacological treatments, such as appetite suppressants (e.g., liraglutide) or binge eating medications (e.g., lisdexamfetamine), can be used in conjunction with lifestyle modifications for obesity and binge eating disorder
  • Bariatric surgery, such as gastric bypass or sleeve gastrectomy, can be an effective treatment for severe obesity when lifestyle interventions have been unsuccessful
  • Nutritional education and counseling can help individuals make informed food choices, develop balanced eating habits, and maintain a healthy body weight
  • Research on the gut-brain axis is exploring the role of the gut microbiome in regulating appetite, metabolism, and eating behavior
  • Personalized nutrition approaches, based on individual genetic, metabolic, and microbiome profiles, are being investigated to optimize dietary interventions and improve health outcomes
  • Innovative technologies, such as smartphone apps and wearable devices, are being developed to monitor eating habits, provide personalized feedback, and support behavior change


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© 2024 Fiveable Inc. All rights reserved.
AP® and SAT® are trademarks registered by the College Board, which is not affiliated with, and does not endorse this website.