Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
The smooth endoplasmic reticulum (SER) is a type of endoplasmic reticulum lacking ribosomes on its surface. It is primarily involved in lipid synthesis, detoxification, and calcium ion storage within cells.
5 Must Know Facts For Your Next Test
The SER is involved in the synthesis of lipids, including phospholipids and steroids.
It plays a critical role in detoxifying chemicals and metabolizing drugs in liver cells.
SER stores and releases calcium ions, which are essential for muscle contraction and various signaling pathways.
Unlike the rough endoplasmic reticulum, the SER does not have ribosomes attached to its membrane.
Cells that produce large amounts of hormones or lipids often have an abundance of smooth endoplasmic reticulum.