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from class: Microbiology Definition Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. It acts as an endotoxin and can trigger strong immune responses in humans.
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Predict what's on your test 5 Must Know Facts For Your Next Test LPS is found in the outer membrane of Gram-negative bacteria such as Escherichia coli and Salmonella. LPS consists of three parts: lipid A, core polysaccharide, and O-antigen. The lipid A component is responsible for the toxic effects associated with LPS. LPS can cause septic shock if it enters the bloodstream in significant amounts. Detection of LPS in clinical samples can indicate a bacterial infection, especially in gastrointestinal diseases. Review Questions What are the three components of lipopolysaccharide? How does lipopolysaccharide contribute to septic shock? Why is lipopolysaccharide significant in diagnosing bacterial infections? "Lipopolysaccharide" also found in:
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