Intro to Psychology

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Barbiturates

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Intro to Psychology

Definition

Barbiturates are a class of central nervous system depressant drugs that were once commonly used as sedatives, hypnotics, and anticonvulsants. They work by enhancing the effects of gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter, to produce a calming and sleep-inducing effect in the body.

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5 Must Know Facts For Your Next Test

  1. Barbiturates were once widely prescribed for their sedative and anticonvulsant properties, but their use has declined due to the development of safer and more effective alternatives, such as benzodiazepines.
  2. Barbiturates have a high potential for abuse and dependence, as they can produce a euphoric, calming effect similar to alcohol intoxication.
  3. Overdose of barbiturates can lead to respiratory depression, coma, and even death, making them particularly dangerous when combined with other central nervous system depressants like alcohol.
  4. Sudden discontinuation of barbiturates can result in severe withdrawal symptoms, including anxiety, tremors, seizures, and even life-threatening complications.
  5. Barbiturates are classified as Schedule II or III controlled substances, indicating their accepted medical use but also their high potential for abuse and dependence.

Review Questions

  • Explain the mechanism of action of barbiturates and how they influence the brain's neurotransmitter systems.
    • Barbiturates exert their effects by enhancing the activity of the inhibitory neurotransmitter GABA in the central nervous system. They bind to specific receptor sites on GABA-A receptors, increasing the frequency of chloride channel openings and resulting in a hyperpolarization of the postsynaptic neuron. This increased inhibitory tone leads to a reduction in neuronal excitability, producing the sedative, hypnotic, and anticonvulsant effects associated with barbiturate use.
  • Describe the potential risks and dangers associated with the use and abuse of barbiturates.
    • Barbiturates have a high potential for abuse and dependence due to their ability to produce a euphoric, calming effect similar to alcohol intoxication. Overdose of barbiturates can lead to respiratory depression, coma, and even death, particularly when combined with other central nervous system depressants like alcohol. Additionally, sudden discontinuation of barbiturates can result in severe withdrawal symptoms, including anxiety, tremors, seizures, and even life-threatening complications, making them a dangerous class of drugs to use or abuse.
  • Analyze the historical context and the decline in the use of barbiturates in favor of alternative medications, such as benzodiazepines.
    • Barbiturates were once widely prescribed for their sedative and anticonvulsant properties, but their use has declined due to the development of safer and more effective alternatives, such as benzodiazepines. This shift in medical practice was driven by the recognition of the high potential for abuse and dependence associated with barbiturates, as well as the increased risk of severe and potentially life-threatening side effects, particularly in cases of overdose. The emergence of benzodiazepines, which offer similar therapeutic benefits but with a better safety profile and lower abuse potential, has largely replaced barbiturates in clinical settings, reflecting the ongoing evolution of pharmacological treatments and the prioritization of patient safety.
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