Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
The sense strand, also known as the coding strand, is the DNA strand that carries the genetic code for a protein. It is identical in sequence to the mRNA except for thymine (T) in place of uracil (U).
5 Must Know Facts For Your Next Test
The sense strand runs in a 5' to 3' direction.
It serves as a template for mRNA synthesis during transcription.
The complementary strand to the sense strand is called the antisense or template strand.
In RNA transcription, only one of the two DNA strands serves as a template at any given time.
The mRNA sequence synthesized from the antisense strand will be complementary to it and identical to the sense strand.
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Related terms
Antisense Strand: The DNA strand that serves as a template for mRNA synthesis.
mRNA (messenger RNA): The RNA molecule transcribed from DNA that carries genetic information from the nucleus to ribosomes for protein synthesis.