Benzimidazoles

Definition

Benzimidazoles are a class of antimicrobial drugs that inhibit the synthesis of microtubules, disrupting cell division. They are commonly used against parasitic worms and fungi.

5 Must Know Facts For Your Next Test

1. Benzimidazoles interfere with the polymerization of tubulin into microtubules.
2. They are effective against a range of parasitic helminths, including nematodes and cestodes.
3. Common benzimidazole drugs include albendazole, mebendazole, and thiabendazole.
4. Resistance to benzimidazoles can occur through mutations in the beta-tubulin gene.
5. Benzimidazoles have a broad spectrum of activity but are mainly used in veterinary medicine.

Related terms

Microtubules:

Cytoskeletal structures involved in cell division and intracellular transport.

Albendazole:

A widely used benzimidazole drug effective against various parasitic worms.

Anthelmintics: Drugs that expel or destroy parasitic worms (helminths).