Intro to Computational Biology
Metadynamics is a computational technique used to explore the free energy landscape of complex systems by adding a bias potential to encourage the sampling of rare events. This method helps overcome energy barriers that typically hinder the exploration of conformational states, making it particularly useful in studying processes like protein folding and determining free energy differences between states. By systematically adding Gaussian-shaped potentials in regions of the configuration space, metadynamics efficiently samples the relevant pathways and provides insight into thermodynamic properties.
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