Computational Chemistry
Metadynamics is an enhanced sampling technique used in molecular simulations to explore free energy landscapes by periodically adding a bias potential to prevent the system from getting trapped in local minima. This method helps to accelerate the sampling of rare events and allows for a more thorough exploration of the conformational space of complex systems. By modifying the potential energy surface, metadynamics facilitates the analysis of molecular dynamics trajectories and aids in accurate entropy and free energy determinations.
congrats on reading the definition of Metadynamics. now let's actually learn it.