Karp's 21 Problems refer to a collection of 21 decision problems that Richard Karp identified as NP-complete in his seminal 1972 paper. These problems are significant because they provide a foundational understanding of NP-completeness and showcase the diversity of challenges that can be reduced to one another. Each problem in this set has implications in various fields such as computer science, operations research, and artificial intelligence, illustrating the central role of reductions in establishing NP-completeness.
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