Mass-energy equivalence, a cornerstone of modern physics, states that mass and energy are interchangeable. Einstein's famous equation E=mc² expresses this relationship, revealing that even a small amount of matter contains an enormous amount of energy due to the speed of light being squared. This concept, proposed by Einstein in 1905, revolutionized our understanding of the universe. It explains nuclear reactions, powers stars, and underlies technologies like nuclear energy and PET scans. Mass-energy equivalence continues to influence research in particle physics and cosmology.