💊Pharmacology for Nurses Unit 34 – Diuretic Drugs

What Are Diuretics?

• Medications that increase urine production and promote the excretion of excess fluid from the body
• Work by acting on the kidneys to enhance the elimination of sodium and water, leading to increased urine output (diuresis)
• Commonly referred to as "water pills" due to their ability to reduce fluid retention and edema
• Help to regulate blood pressure by decreasing the volume of fluid circulating in the bloodstream
• Can be used to manage various conditions characterized by fluid overload (congestive heart failure, kidney disorders, liver disease)
• Different classes of diuretics exist, each with distinct mechanisms of action and effects on the body
• Diuretics are often used in combination with other medications to achieve optimal therapeutic outcomes

Types of Diuretic Drugs

• Loop diuretics (furosemide, bumetanide, torsemide) are the most potent and act on the loop of Henle in the nephron
  • Inhibit the sodium-potassium-chloride cotransporter, leading to increased excretion of these electrolytes and water
• Thiazide diuretics (hydrochlorothiazide, chlorthalidone, metolazone) act on the distal convoluted tubule
  • Inhibit the sodium-chloride cotransporter, promoting the excretion of sodium and water
• Potassium-sparing diuretics (spironolactone, eplerenone, triamterene, amiloride) act on the collecting duct
  • Reduce potassium excretion by blocking sodium channels or inhibiting aldosterone activity
• Carbonic anhydrase inhibitors (acetazolamide) act on the proximal convoluted tubule
  • Inhibit the enzyme carbonic anhydrase, leading to increased bicarbonate excretion and reduced sodium reabsorption
• Osmotic diuretics (mannitol) work by increasing the osmotic pressure within the tubular lumen
  • Draw water into the tubules, leading to increased urine output and reduced intracranial pressure

How Diuretics Work

• Act on different segments of the nephron to inhibit the reabsorption of sodium and water, leading to increased urine production
• Loop diuretics inhibit the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle
  • Resulting in decreased reabsorption of these electrolytes and increased excretion of water
• Thiazide diuretics block the sodium-chloride cotransporter in the distal convoluted tubule
  • Promoting the excretion of sodium and water while retaining potassium
• Potassium-sparing diuretics either block sodium channels in the collecting duct (amiloride, triamterene) or inhibit aldosterone activity (spironolactone, eplerenone)
  • Reducing potassium excretion and increasing sodium and water excretion
• Carbonic anhydrase inhibitors block the enzyme carbonic anhydrase in the proximal convoluted tubule
  • Leading to increased bicarbonate excretion and reduced sodium reabsorption
• Osmotic diuretics create an osmotic gradient in the tubular lumen, drawing water into the tubules and increasing urine output

Common Uses and Indications

• Management of hypertension by reducing blood volume and decreasing peripheral vascular resistance
• Treatment of edema associated with congestive heart failure, kidney disorders, and liver disease
  • Diuretics help to alleviate symptoms such as shortness of breath, swelling, and fluid accumulation
• Prevention of fluid overload in patients with chronic kidney disease or end-stage renal disease
• Reduction of intracranial pressure in patients with cerebral edema or increased intracranial pressure (mannitol)
• Management of calcium nephrolithiasis by increasing urine output and reducing urinary calcium concentration (thiazide diuretics)
• Treatment of glaucoma by reducing intraocular pressure (carbonic anhydrase inhibitors)
• Correction of electrolyte imbalances, such as hyperkalemia or hypercalcemia

Side Effects and Precautions

• Electrolyte disturbances, including hypokalemia, hyponatremia, hypomagnesemia, and hypochloremic alkalosis
  • Regular monitoring of serum electrolytes is essential, and electrolyte replacement may be necessary
• Volume depletion and dehydration due to excessive fluid loss, especially in elderly patients or those with impaired renal function
• Orthostatic hypotension and dizziness, particularly when initiating therapy or increasing dosage
• Hyperuricemia and gout exacerbation, as diuretics can decrease uric acid excretion (loop and thiazide diuretics)
• Hypersensitivity reactions, such as skin rash, itching, or anaphylaxis, may occur in some patients
• Ototoxicity, characterized by hearing loss or tinnitus, with high doses of loop diuretics
• Potassium-sparing diuretics may cause hyperkalemia, especially in patients with renal impairment or those taking other medications that increase potassium levels

Nursing Considerations

• Assess patient's fluid status, including intake and output, daily weight, and signs of fluid overload or dehydration
• Monitor vital signs, particularly blood pressure and orthostatic changes, to detect hypotension or volume depletion
• Regularly check serum electrolyte levels and renal function tests to identify and manage electrolyte disturbances or renal impairment
• Administer diuretics at the prescribed time and dose, and ensure proper documentation of administration
• Encourage patients to report any adverse effects, such as dizziness, muscle cramps, or hearing changes
• Educate patients on the importance of maintaining adequate fluid intake and a balanced diet to prevent dehydration and electrolyte imbalances
• Collaborate with the healthcare team to adjust diuretic therapy based on patient response and laboratory findings

Drug Interactions

• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the efficacy of diuretics and increase the risk of renal impairment
• ACE inhibitors and angiotensin receptor blockers (ARBs) may potentiate the hypotensive effects of diuretics and increase the risk of hyperkalemia when used with potassium-sparing diuretics
• Digoxin toxicity may occur due to diuretic-induced electrolyte disturbances, particularly hypokalemia and hypomagnesemia
• Lithium toxicity may be enhanced by thiazide and loop diuretics, as they reduce lithium excretion
• Corticosteroids may exacerbate the potassium-depleting effects of loop and thiazide diuretics
• Certain antibiotics (aminoglycosides, cephalosporins) may increase the risk of nephrotoxicity and ototoxicity when used with loop diuretics

Patient Education Tips

• Emphasize the importance of taking diuretics as prescribed and not adjusting the dose without consulting the healthcare provider
• Advise patients to weigh themselves daily and report significant changes to their healthcare provider
• Encourage patients to maintain a balanced diet with adequate potassium intake (fruits, vegetables) when taking non-potassium-sparing diuretics
• Instruct patients to rise slowly from a sitting or lying position to minimize the risk of orthostatic hypotension
• Advise patients to avoid excessive alcohol consumption, as it can exacerbate the dehydrating effects of diuretics
• Educate patients on the signs and symptoms of electrolyte imbalances (muscle cramps, weakness, irregular heartbeat) and the importance of reporting these to their healthcare provider
• Remind patients to inform all healthcare providers about their diuretic use, as it may influence the choice and dosage of other medications