The equation e=mc², formulated by Albert Einstein, expresses the principle of mass-energy equivalence, stating that energy (e) is equal to mass (m) multiplied by the speed of light (c) squared. This powerful relationship reveals that mass can be converted into energy and vice versa, which has profound implications in fields like nuclear physics and cosmology. Understanding this equation is crucial for comprehending processes like nuclear reactions, where significant amounts of energy are released as mass is converted into energy.