Energy-mass equivalence is the principle that states that energy and mass are interchangeable; they are different forms of the same thing. This concept is famously expressed in Einstein's equation, $$E=mc^2$$, which shows that a small amount of mass can be converted into a large amount of energy. This principle underlies many processes in physics, including nuclear fusion, where mass is transformed into energy, playing a critical role in the processes that power stars and lead to the synthesis of new elements.