PCSK9 inhibitors are a class of drugs that lower LDL cholesterol levels by inhibiting the protein PCSK9, which increases the liver's ability to remove LDL from the blood. They are often used for patients who do not respond adequately to statins or have familial hypercholesterolemia.
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A genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL), due to a mutation affecting LDL receptor function.