The Na+-K+-2Cl- cotransporter, also known as the NKCC, is a specialized membrane protein that simultaneously transports sodium (Na+), potassium (K+), and chloride (Cl-) ions across the cell membrane. This electroneutral cotransporter plays a crucial role in various physiological processes, particularly in the context of diuretics, which are medications used to treat conditions like hypertension, edema, and kidney disorders.
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