Antithyroid drugs
from class: Pharmacology for Nurses Definition Antithyroid drugs are medications used to manage hyperthyroidism by inhibiting the production of thyroid hormones. Commonly prescribed antithyroid drugs include methimazole and propylthiouracil (PTU).
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Predict what's on your test 5 Must Know Facts For Your Next Test Methimazole is generally preferred over PTU due to its longer half-life and lower risk of liver toxicity. PTU is preferred during the first trimester of pregnancy due to lesser teratogenic effects compared to methimazole. Antithyroid drugs can cause adverse effects such as agranulocytosis, which requires regular monitoring of white blood cell counts. Both methimazole and PTU inhibit the enzyme thyroid peroxidase, reducing the synthesis of thyroxine (T4) and triiodothyronine (T3). Patients on antithyroid drugs need regular follow-up to monitor thyroid function tests and adjust dosages accordingly. Review Questions What is the primary mechanism of action for antithyroid drugs? Why might PTU be preferred over methimazole during the first trimester of pregnancy? What serious side effect should be monitored in patients taking antithyroid drugs?
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