Streptococcal toxic shock syndrome (STSS)

Definition

Streptococcal Toxic Shock Syndrome (STSS) is a severe illness caused by Streptococcus pyogenes, characterized by sudden onset of shock and organ failure. It often starts with respiratory tract infections and rapidly progresses to systemic involvement.

5 Must Know Facts For Your Next Test

1. STSS is associated with the bacterium Streptococcus pyogenes, which can also cause strep throat and skin infections.
2. Symptoms of STSS include high fever, low blood pressure, rash, and multi-organ failure.
3. The rapid progression of STSS requires immediate medical intervention, including antibiotics and supportive care.
4. Superantigens produced by Streptococcus pyogenes play a key role in the pathogenesis of STSS by triggering an excessive immune response.
5. STSS can follow invasive streptococcal infections such as pneumonia or cellulitis.

Review Questions

• What bacterium is responsible for causing Streptococcal Toxic Shock Syndrome?
• List three major symptoms of STSS.
• How do superantigens contribute to the severity of STSS?

Related terms

Streptococcus pyogenes: A type of bacteria that causes various infections including strep throat, impetigo, and necrotizing fasciitis.

Superantigen: A class of antigens that result in excessive activation of the immune system.

Toxic Shock Syndrome (TSS): A similar condition to STSS but often caused by Staphylococcus aureus.