🦠microbiology review

Oral herpes

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

Oral herpes is a viral infection caused by the herpes simplex virus type 1 (HSV-1) that typically manifests as cold sores or fever blisters around the mouth and lips. It is highly contagious and can spread through direct contact with infected saliva or lesions.

5 Must Know Facts For Your Next Test

  1. HSV-1 is the primary cause of oral herpes, but HSV-2 can also cause oral infections.
  2. The initial outbreak of oral herpes can be severe, often accompanied by systemic symptoms like fever and swollen lymph nodes.
  3. The virus remains latent in the nerve cells and can reactivate, causing recurrent outbreaks.
  4. Antiviral medications such as acyclovir can help reduce the severity and frequency of outbreaks but do not cure the infection.
  5. Oral herpes is often diagnosed based on clinical appearance, but laboratory tests like PCR or viral culture can confirm the diagnosis.

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