Graft-versus-host disease (GVHD)
from class: Microbiology Definition Graft-versus-host disease (GVHD) is a medical condition that occurs when donor immune cells attack the recipient's tissues after an organ or bone marrow transplant. It primarily affects the skin, liver, and gastrointestinal tract.
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Predict what's on your test 5 Must Know Facts For Your Next Test GVHD is classified into acute and chronic forms based on the timing and manifestation of symptoms. Acute GVHD typically develops within the first 100 days post-transplant, while chronic GVHD occurs later. Symptoms of acute GVHD include rashes, jaundice, and gastrointestinal issues like diarrhea. Chronic GVHD can lead to long-term complications such as fibrosis and organ dysfunction. Immunosuppressive therapies are commonly used to manage and prevent GVHD. Review Questions What are the primary organs affected by graft-versus-host disease? Differentiate between acute and chronic GVHD in terms of onset time and symptoms. How is graft-versus-host disease typically managed in patients?
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