Genomics
Beckwith-Wiedemann Syndrome (BWS) is a genetic disorder characterized by overgrowth and various congenital abnormalities, often resulting from abnormal regulation of growth-related genes. This syndrome is closely linked to epigenetic changes, particularly in DNA methylation patterns that affect the expression of genes involved in growth, such as IGF2, which is crucial for fetal development. Understanding the epigenetic aspects of BWS sheds light on how these modifications can lead to the disorder's clinical features.
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