The Erdős-Szekeres Theorem is a fundamental result in combinatorial mathematics that states any sequence of at least $n^2$ distinct real numbers contains a monotonically increasing subsequence of length at least $n$ or a monotonically decreasing subsequence of length at least $n$. This theorem is significant because it introduces key concepts related to the structure of sequences and lays the groundwork for various proof techniques used in extremal combinatorics.
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