Existential distress refers to the profound emotional and psychological discomfort individuals experience when confronting fundamental questions about existence, meaning, and the inevitability of death. This type of distress often arises during end-of-life situations, where individuals may grapple with feelings of uncertainty, fear, and loss of control. In the context of end-of-life care and decision-making, understanding existential distress is crucial for providing comprehensive support to patients and their families.