Computational Genomics
In the context of de novo assembly in genomics, Trinity is an open-source software package designed for reconstructing transcriptomes from RNA-Seq data. It efficiently assembles transcripts by handling complex data, allowing researchers to analyze gene expression and discover novel transcripts without prior knowledge of the reference genome. Trinity utilizes a three-step approach: Inchworm, Chrysalis, and Butterfly, which work together to process raw sequencing reads into a comprehensive representation of expressed genes.
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