Biological Chemistry II
HMG-CoA synthase is an enzyme that plays a crucial role in the biosynthesis of ketone bodies from acetyl-CoA during periods of fasting, low carbohydrate intake, or untreated diabetes. This enzyme catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA to form HMG-CoA, a key intermediate in ketogenesis, linking carbohydrate metabolism to lipid metabolism and energy production.
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