Biological Chemistry II
Histone modifications refer to the chemical changes that occur on the amino acids of histone proteins, which play a critical role in the regulation of gene expression and chromatin structure. These modifications, including methylation, acetylation, phosphorylation, and ubiquitination, can influence how tightly DNA is packaged around histones, thus impacting accessibility for transcription machinery. This process is particularly relevant in understanding how lifestyle factors and metabolic disorders can affect gene expression related to obesity and overall metabolism.
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