💀Anatomy and Physiology I Unit 25 – The Urinary System

Key Structures and Functions

• The urinary system consists of the kidneys, ureters, bladder, and urethra which work together to filter blood, remove waste products, and maintain fluid and electrolyte balance
• Kidneys are bean-shaped organs located in the retroperitoneal space that filter blood to produce urine (approximately 180 liters per day)
• Ureters are muscular tubes that transport urine from the kidneys to the bladder using peristaltic contractions
• The bladder is a hollow, muscular organ that stores urine (up to 500-600 mL) until it is expelled from the body through the urethra
• The urethra is a tube that carries urine from the bladder to the outside of the body (shorter in females, longer in males)
• Kidneys also produce hormones such as erythropoietin (stimulates red blood cell production), renin (regulates blood pressure), and calcitriol (active form of vitamin D)
• The urinary system helps maintain homeostasis by regulating blood volume, blood pressure, pH, and electrolyte concentrations

Kidney Anatomy and Nephron Structure

• Kidneys are divided into the outer cortex and inner medulla, with the medulla consisting of renal pyramids separated by renal columns
• The functional unit of the kidney is the nephron, with each kidney containing approximately 1 million nephrons
• Nephrons consist of the renal corpuscle (glomerulus and Bowman's capsule) and the renal tubule (proximal convoluted tubule, loop of Henle, distal convoluted tubule, and collecting duct)
• The glomerulus is a network of capillaries surrounded by Bowman's capsule, where blood is filtered to form the glomerular filtrate
  • Podocytes are specialized cells that wrap around the glomerular capillaries and create filtration slits, allowing small molecules to pass through while retaining larger molecules
• The renal tubule is responsible for reabsorption and secretion of substances, ultimately producing urine
  • The proximal convoluted tubule reabsorbs the majority of the glomerular filtrate (glucose, amino acids, water, and ions)
  • The loop of Henle creates a concentration gradient in the medulla, allowing for the concentration of urine
  • The distal convoluted tubule and collecting duct are responsible for fine-tuning the composition of urine and responding to hormonal signals

Urine Formation Process

• Urine formation involves three main processes: glomerular filtration, tubular reabsorption, and tubular secretion
• Glomerular filtration occurs in the renal corpuscle, where blood is filtered under pressure, creating the glomerular filtrate
  • The filtration barrier consists of the fenestrated endothelium, basement membrane, and podocyte filtration slits
  • Molecules smaller than 7 nm (such as water, glucose, amino acids, and ions) freely pass through the filtration barrier, while larger molecules (proteins and blood cells) are retained
• Tubular reabsorption occurs along the renal tubule, where essential substances are selectively transported back into the bloodstream
  • The proximal convoluted tubule reabsorbs the majority of the glomerular filtrate (65-80%), including glucose, amino acids, and ions via active transport and water via osmosis
  • The loop of Henle reabsorbs water and ions, creating a concentration gradient in the medulla
  • The distal convoluted tubule and collecting duct fine-tune the composition of urine by reabsorbing or secreting substances based on hormonal signals (aldosterone and antidiuretic hormone)
• Tubular secretion is the process by which substances are actively transported from the peritubular capillaries into the renal tubule lumen
  • This process helps to eliminate waste products (hydrogen ions, potassium, and organic acids) and regulate blood pH
• The final product, urine, is then transported through the ureters to the bladder for storage and eventual elimination via the urethra

Regulation of Water and Electrolytes

• The kidneys play a crucial role in maintaining fluid and electrolyte balance in the body
• Water balance is regulated by the antidiuretic hormone (ADH or vasopressin), which is released from the posterior pituitary gland in response to increased blood osmolarity or decreased blood volume
  • ADH increases water reabsorption in the collecting ducts by inserting aquaporin channels into the luminal membrane, leading to the production of concentrated urine
  • In the absence of ADH, the collecting ducts are impermeable to water, resulting in the production of dilute urine
• Sodium balance is regulated by aldosterone, a mineralocorticoid hormone produced by the adrenal cortex in response to decreased blood volume or increased potassium levels
  • Aldosterone increases sodium reabsorption and potassium secretion in the distal convoluted tubule and collecting duct, leading to increased water retention and blood volume
• The renin-angiotensin-aldosterone system (RAAS) is a hormonal cascade that regulates blood pressure and fluid balance
  • Decreased blood pressure or reduced sodium delivery to the distal tubule stimulates the release of renin from the juxtaglomerular cells
  • Renin converts angiotensinogen to angiotensin I, which is then converted to angiotensin II by angiotensin-converting enzyme (ACE)
  • Angiotensin II stimulates the release of aldosterone, leading to increased sodium and water retention, and vasoconstriction, ultimately raising blood pressure
• The kidneys also regulate the balance of other electrolytes, such as potassium, calcium, and phosphate, through various hormonal and transport mechanisms

Acid-Base Balance

• The kidneys play a vital role in maintaining the body's acid-base balance by regulating the excretion of hydrogen ions (H+) and the reabsorption of bicarbonate ions (HCO3-)
• The proximal convoluted tubule reabsorbs the majority of the filtered bicarbonate (80-90%) via the action of carbonic anhydrase and sodium-hydrogen exchangers
  • Carbonic anhydrase catalyzes the conversion of H2O and CO2 to H+ and HCO3-, allowing for the secretion of H+ into the tubule lumen and the reabsorption of HCO3- into the peritubular capillaries
• The distal convoluted tubule and collecting duct are responsible for fine-tuning the acid-base balance by secreting H+ and reabsorbing HCO3- in response to changes in blood pH
  • In acidosis (low blood pH), the kidneys increase H+ secretion and generate new bicarbonate through the action of glutaminase and ammoniagenesis
  • In alkalosis (high blood pH), the kidneys decrease H+ secretion and excrete excess bicarbonate
• The kidneys also excrete titratable acids (phosphate and sulfate buffers) and ammonia to help buffer excess H+ in the urine
• The renin-angiotensin-aldosterone system indirectly affects acid-base balance by regulating sodium and potassium levels, which influence H+ secretion in the distal nephron

Common Urinary System Disorders

• Urinary tract infections (UTIs) are caused by bacterial growth in the urethra, bladder, or kidneys, leading to symptoms such as frequent urination, burning sensation, and cloudy or bloody urine
  • Risk factors include female anatomy (shorter urethra), sexual activity, and urinary stasis
• Kidney stones (renal calculi) are hard deposits of minerals and salts that form in the kidneys and can cause severe pain, nausea, and hematuria
  • Common types include calcium oxalate, calcium phosphate, uric acid, and struvite stones
  • Risk factors include dehydration, high-protein diets, and certain genetic disorders
• Glomerulonephritis is an inflammation of the glomeruli, often caused by an autoimmune response or infection, leading to hematuria, proteinuria, and edema
• Acute kidney injury (AKI) is a rapid decline in kidney function due to factors such as dehydration, sepsis, or nephrotoxic drugs, resulting in decreased urine output and accumulation of waste products
• Chronic kidney disease (CKD) is a gradual loss of kidney function over time, often caused by diabetes, hypertension, or glomerulonephritis, leading to the accumulation of waste products and electrolyte imbalances
• Polycystic kidney disease (PKD) is an inherited disorder characterized by the development of multiple fluid-filled cysts in the kidneys, leading to enlarged kidneys and progressive loss of function
• Renal cell carcinoma is a type of kidney cancer that originates in the lining of the proximal convoluted tubule and can cause symptoms such as hematuria, flank pain, and a palpable abdominal mass

Clinical Applications and Diagnostics

• Urinalysis is a common diagnostic test that evaluates the physical, chemical, and microscopic properties of urine to detect various urinary system disorders
  • Physical properties include color, clarity, and specific gravity
  • Chemical properties are assessed using dipstick tests for pH, protein, glucose, ketones, blood, and leukocyte esterase
  • Microscopic examination identifies cells (red blood cells, white blood cells, and epithelial cells), casts, crystals, and bacteria
• Blood tests, such as serum creatinine and blood urea nitrogen (BUN), are used to assess kidney function and filtration rate
  • Elevated levels of creatinine and BUN indicate reduced kidney function or damage
• Imaging techniques, such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), are used to visualize the structure and detect abnormalities of the kidneys, ureters, and bladder
  • These techniques can identify kidney stones, tumors, cysts, and obstructions
• Renal biopsy involves obtaining a small sample of kidney tissue for microscopic examination to diagnose conditions such as glomerulonephritis, interstitial nephritis, and renal tumors
• Cystoscopy is a procedure that uses a thin, flexible tube with a light and camera (cystoscope) to examine the inside of the bladder and urethra for abnormalities or to obtain tissue samples
• Urodynamic tests evaluate the function of the bladder and urethra during filling and emptying to diagnose conditions such as urinary incontinence, overactive bladder, and bladder outlet obstruction
• Treatment options for urinary system disorders vary depending on the specific condition and may include antibiotics, pain management, surgical interventions, and lifestyle modifications (hydration, dietary changes, and weight management)

Connections to Other Body Systems

• The urinary system interacts closely with the cardiovascular system to maintain blood pressure and fluid balance
  • The kidneys regulate blood volume by adjusting sodium and water excretion, which affects blood pressure
  • The renin-angiotensin-aldosterone system (RAAS) is a hormonal cascade that involves the kidneys, lungs, and adrenal glands to regulate blood pressure and fluid balance
• The urinary system works with the endocrine system to produce and respond to hormones that regulate various functions
  • The kidneys produce erythropoietin, which stimulates red blood cell production in the bone marrow
  • The kidneys also produce calcitriol (active vitamin D), which regulates calcium and phosphate homeostasis and bone metabolism
  • Antidiuretic hormone (ADH) from the posterior pituitary gland and aldosterone from the adrenal cortex act on the kidneys to regulate water and sodium balance
• The urinary system helps maintain acid-base balance in coordination with the respiratory system and buffer systems in the blood
  • The kidneys excrete excess hydrogen ions and reabsorb bicarbonate to compensate for changes in blood pH
  • The respiratory system helps regulate blood pH by adjusting the rate and depth of breathing to alter carbon dioxide levels
• The urinary system eliminates waste products from the digestive system, such as urea (a byproduct of protein metabolism) and excess electrolytes
• The urinary system also eliminates waste products from the metabolism of drugs and toxins processed by the liver
• Disorders of the urinary system can affect other body systems, such as:
  • Chronic kidney disease can lead to anemia (decreased red blood cell production), bone mineral disorders (due to altered calcium and phosphate balance), and cardiovascular disease (due to hypertension and fluid overload)
  • Urinary tract infections can spread to the bloodstream (sepsis) and cause systemic inflammation and organ dysfunction
  • Kidney stones can cause obstruction and damage to the urinary tract, leading to pain, infection, and potential loss of kidney function