💀Anatomy and Physiology I Unit 22 – The Respiratory System

Overview and Structure

• The respiratory system facilitates gas exchange between the external environment and the body's cells
• Consists of the upper respiratory tract (nose, pharynx, and larynx) and lower respiratory tract (trachea, bronchi, and lungs)
• The lungs are the primary organs of the respiratory system where gas exchange occurs
• The diaphragm, a muscular sheet located below the lungs, plays a crucial role in breathing
• The respiratory system works in close coordination with the cardiovascular system to deliver oxygen and remove carbon dioxide from the body
• The respiratory system also plays a role in maintaining acid-base balance, producing sound (phonation), and protecting against inhaled pathogens and irritants
• The respiratory system is lined with mucous membranes that help humidify, warm, and filter inspired air

Anatomy of the Respiratory System

• The nose is the primary entry point for inspired air and contains nasal conchae that help warm, humidify, and filter air
• The pharynx is a passageway that connects the nose and mouth to the larynx and esophagus
  • Divided into three regions: nasopharynx, oropharynx, and laryngopharynx
• The larynx, or voice box, contains the vocal cords and connects the pharynx to the trachea
• The trachea is a cartilaginous tube that extends from the larynx to the primary bronchi
  • Lined with pseudostratified ciliated columnar epithelium and contains C-shaped cartilage rings for support
• The primary bronchi branch from the trachea and lead to the right and left lungs
• The lungs are paired, cone-shaped organs located in the thoracic cavity
  • Right lung has three lobes (upper, middle, and lower) while the left lung has two lobes (upper and lower)
• The bronchial tree consists of the primary bronchi, secondary (lobar) bronchi, tertiary (segmental) bronchi, and smaller bronchioles
• Alveoli are the functional units of the lungs where gas exchange takes place
  • Surrounded by a network of capillaries for efficient gas exchange

Mechanics of Breathing

• Breathing, or ventilation, involves the movement of air into (inspiration) and out of (expiration) the lungs
• Inspiration is an active process involving the contraction of the diaphragm and external intercostal muscles
  • Diaphragm contraction causes it to flatten, increasing the vertical dimension of the thoracic cavity
  • External intercostal muscle contraction elevates the ribs, increasing the anterior-posterior dimension of the thoracic cavity
• Expiration is typically a passive process involving the relaxation of the diaphragm and external intercostal muscles
  • Elastic recoil of the lungs and thoracic wall helps to expel air during quiet expiration
• During forced expiration, internal intercostal muscles and abdominal muscles contract to increase the force of exhalation
• Changes in intrapulmonary pressure and intrathoracic pressure during breathing facilitate air movement
• Compliance refers to the ease with which the lungs and thoracic wall expand
  • Affected by factors such as age, disease, and physical condition
• Airway resistance influences the rate of air flow and is affected by factors such as airway diameter, inflammation, and mucus production

Gas Exchange and Transport

• Gas exchange occurs between the alveoli and the pulmonary capillaries in the lungs
• Oxygen diffuses from the alveoli into the blood, while carbon dioxide diffuses from the blood into the alveoli
• The partial pressure gradient of oxygen and carbon dioxide drives the diffusion process
  • Oxygen moves from an area of high partial pressure (alveoli) to an area of low partial pressure (blood)
  • Carbon dioxide moves from an area of high partial pressure (blood) to an area of low partial pressure (alveoli)
• Hemoglobin, an oxygen-binding protein in red blood cells, facilitates the transport of oxygen in the blood
  • Each hemoglobin molecule can bind up to four oxygen molecules
• The oxygen-hemoglobin dissociation curve demonstrates the relationship between oxygen partial pressure and hemoglobin saturation
  • Factors such as pH, temperature, and 2,3-bisphosphoglycerate (2,3-BPG) affect the affinity of hemoglobin for oxygen
• Carbon dioxide is transported in the blood in three forms: dissolved in plasma, bound to hemoglobin (carbaminohemoglobin), and as bicarbonate ions
• The Bohr effect describes how the presence of carbon dioxide and low pH decreases hemoglobin's affinity for oxygen, facilitating oxygen release in tissues

Control of Respiration

• Respiratory rate and depth are regulated by the respiratory center in the medulla oblongata and pons of the brainstem
• The dorsal respiratory group (DRG) in the medulla is responsible for generating the basic rhythm of breathing
• The ventral respiratory group (VRG) in the medulla helps to coordinate the activity of respiratory muscles
• The pneumotaxic center in the pons modulates the duration of inspiration and the transition to expiration
• Central chemoreceptors in the medulla detect changes in cerebrospinal fluid pH and adjust respiration accordingly
  • Increased carbon dioxide levels lead to increased respiratory rate and depth
• Peripheral chemoreceptors (carotid and aortic bodies) detect changes in arterial blood oxygen, carbon dioxide, and pH levels
• Stretch receptors in the lungs (pulmonary stretch receptors) help to prevent overinflation and contribute to the Hering-Breuer reflex
• Higher brain centers, such as the cerebral cortex and hypothalamus, can voluntarily modify respiration (e.g., during speech or singing)

Common Respiratory Disorders

• Asthma is a chronic inflammatory disorder characterized by airway hyperresponsiveness and reversible airflow obstruction
  • Triggered by factors such as allergens, exercise, and cold air
• Chronic obstructive pulmonary disease (COPD) is a progressive condition that includes chronic bronchitis and emphysema
  • Characterized by airflow limitation and persistent respiratory symptoms
• Pneumonia is an infection of the lungs caused by bacteria, viruses, or fungi
  • Leads to inflammation and fluid accumulation in the alveoli
• Lung cancer is a malignant tumor that originates in the lungs
  • Risk factors include smoking, exposure to radon and asbestos, and family history
• Sleep apnea is a disorder characterized by repeated pauses in breathing during sleep
  • Can be obstructive (due to airway collapse) or central (due to impaired respiratory drive)
• Pulmonary embolism is a blockage of a pulmonary artery, usually by a blood clot that originates in the deep veins of the legs
  • Can cause chest pain, shortness of breath, and potentially life-threatening complications
• Cystic fibrosis is a genetic disorder that affects the lungs and digestive system
  • Characterized by the production of thick, sticky mucus that clogs airways and leads to recurrent infections

Clinical Applications

• Pulmonary function tests (PFTs) are used to assess lung function and diagnose respiratory disorders
  • Spirometry measures the volume and flow of air during inspiration and expiration
  • Lung volumes and capacities provide information about the amount of air in the lungs at different points during the respiratory cycle
• Arterial blood gas (ABG) analysis measures the partial pressures of oxygen and carbon dioxide, as well as pH, in arterial blood
  • Helps to evaluate gas exchange and acid-base balance
• Pulse oximetry is a non-invasive method of measuring oxygen saturation in the blood
  • Uses a sensor placed on the finger, toe, or earlobe to detect changes in light absorption by oxygenated and deoxygenated hemoglobin
• Chest radiography (X-ray) and computed tomography (CT) scans are imaging techniques used to visualize the lungs and detect abnormalities
• Bronchoscopy is a procedure that allows direct visualization of the airways using a flexible or rigid tube with a camera
  • Used for diagnostic purposes and therapeutic interventions (e.g., removing foreign objects or collecting tissue samples)
• Mechanical ventilation is used to support or replace spontaneous breathing in patients with respiratory failure
  • Can be invasive (with an endotracheal tube) or non-invasive (with a face mask or nasal interface)
• Oxygen therapy is used to treat hypoxemia (low blood oxygen levels) and can be delivered through nasal cannulas, face masks, or high-flow nasal cannulas
• Pulmonary rehabilitation is a multidisciplinary program that helps to improve the quality of life and functional capacity of patients with chronic respiratory disorders
  • Includes exercise training, education, and psychosocial support

Key Takeaways and Review

• The respiratory system is responsible for gas exchange between the external environment and the body's cells
• The upper respiratory tract includes the nose, pharynx, and larynx, while the lower respiratory tract consists of the trachea, bronchi, and lungs
• The lungs are the primary organs of gas exchange, with alveoli being the functional units where oxygen and carbon dioxide are exchanged
• Breathing involves the active process of inspiration and the typically passive process of expiration
• Gas exchange occurs by diffusion, driven by partial pressure gradients of oxygen and carbon dioxide between the alveoli and pulmonary capillaries
• Oxygen is primarily transported in the blood bound to hemoglobin, while carbon dioxide is transported in three forms: dissolved in plasma, bound to hemoglobin, and as bicarbonate ions
• Respiration is controlled by the respiratory center in the brainstem, with input from central and peripheral chemoreceptors, as well as higher brain centers
• Common respiratory disorders include asthma, COPD, pneumonia, lung cancer, sleep apnea, pulmonary embolism, and cystic fibrosis
• Clinical applications in the respiratory system include pulmonary function tests, arterial blood gas analysis, pulse oximetry, imaging techniques, bronchoscopy, mechanical ventilation, oxygen therapy, and pulmonary rehabilitation