😵Abnormal Psychology Unit 8 – Depressive and Bipolar Disorders

What's the Deal with Mood Disorders?

• Mood disorders involve significant and persistent disturbances in emotional states
• Affect daily functioning, relationships, and quality of life
• Include major depressive disorder (MDD) and bipolar disorder (BD)
• Characterized by extreme shifts in mood, energy levels, and behavior
• Can occur at any age but often emerge during adolescence or early adulthood
• Affect millions of people worldwide across various cultures and demographics
• Require professional diagnosis and treatment for effective management

Key Players: Major Depression and Bipolar Disorder

• Major depressive disorder (MDD) involves persistent feelings of sadness, hopelessness, and loss of interest in activities
  • Symptoms last for at least two weeks and significantly impair daily functioning
  • Can occur as a single episode or recurrent episodes throughout life
• Bipolar disorder (BD) involves alternating periods of depression and mania or hypomania
  • Mania includes elevated mood, increased energy, reduced need for sleep, and impulsive behavior
  • Hypomania is a milder form of mania without severe impairment in functioning
• BD is classified into two main types:
  • Bipolar I disorder involves at least one manic episode, often with depressive episodes
  • Bipolar II disorder involves hypomanic episodes and depressive episodes without full-blown mania

Spotting the Signs: Symptoms and Diagnosis

• Symptoms of MDD include:
  • Persistent sadness, emptiness, or hopelessness
  • Loss of interest in activities once enjoyed (anhedonia)
  • Changes in appetite and sleep patterns
  • Fatigue and decreased energy
  • Difficulty concentrating and making decisions
  • Feelings of worthlessness or excessive guilt
  • Thoughts of death or suicide
• Symptoms of manic or hypomanic episodes in BD include:
  • Elevated or irritable mood
  • Increased energy and activity levels
  • Reduced need for sleep
  • Racing thoughts and rapid speech
  • Distractibility and impulsivity
  • Inflated self-esteem or grandiosity
  • Engaging in risky behaviors (excessive spending, sexual promiscuity)
• Diagnosis involves a comprehensive evaluation by a mental health professional
  • Assesses symptoms, duration, and impact on functioning
  • Considers medical history, family history, and potential substance use
  • May use standardized diagnostic criteria (DSM-5 or ICD-11)

What's Going On in the Brain?

• Mood disorders involve complex interactions between neurotransmitters, brain circuits, and genetic factors
• Neurotransmitter imbalances, particularly serotonin, norepinephrine, and dopamine, play a role in mood regulation
  • Low levels of serotonin are associated with depressive symptoms
  • Dysregulation of norepinephrine and dopamine may contribute to manic or hypomanic episodes
• Brain imaging studies reveal structural and functional changes in specific regions:
  • Reduced volume and activity in the prefrontal cortex, which regulates emotions and decision-making
  • Altered activity in the amygdala, which processes emotional responses
  • Disrupted communication between the prefrontal cortex and limbic system
• Abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis, which regulates stress response, are observed
  • Chronic stress and trauma can lead to HPA axis dysregulation and increased vulnerability to mood disorders

Nature vs. Nurture: Causes and Risk Factors

• Mood disorders result from a complex interplay of genetic, biological, and environmental factors
• Genetic factors:
  • Family history of mood disorders increases the risk
  • Multiple genes likely contribute to susceptibility rather than a single gene
  • Gene-environment interactions play a significant role in the development of mood disorders
• Biological factors:
  • Neurotransmitter imbalances (serotonin, norepinephrine, dopamine)
  • Abnormalities in brain structure and function
  • Hormonal imbalances (thyroid disorders, postpartum depression)
  • Chronic medical conditions (cardiovascular disease, diabetes)
• Environmental factors:
  • Stressful life events (loss of a loved one, job loss, relationship problems)
  • Childhood trauma or abuse
  • Lack of social support
  • Substance abuse
• Psychological factors:
  • Negative thought patterns and cognitive distortions
  • Low self-esteem and self-worth
  • Maladaptive coping mechanisms
  • Personality traits (neuroticism, perfectionism)

Treatment Time: Meds, Therapy, and More

• Treatment for mood disorders typically involves a combination of medication and psychotherapy
• Medications:
  • Antidepressants (SSRIs, SNRIs, TCAs) help alleviate depressive symptoms by regulating neurotransmitter levels
  • Mood stabilizers (lithium, anticonvulsants) help prevent manic or hypomanic episodes in BD
  • Antipsychotics may be prescribed for severe manic episodes or as adjunctive treatment
• Psychotherapy:
  • Cognitive-behavioral therapy (CBT) helps identify and change negative thought patterns and behaviors
  • Interpersonal therapy (IPT) focuses on improving relationships and communication skills
  • Psychodynamic therapy explores unconscious conflicts and early life experiences
• Lifestyle modifications:
  • Regular exercise and physical activity
  • Balanced diet and nutrition
  • Stress management techniques (mindfulness, relaxation)
  • Establishing a consistent sleep schedule
• Brain stimulation therapies (ECT, TMS) may be considered for treatment-resistant cases
• Complementary and alternative therapies (acupuncture, herbal remedies) lack strong scientific evidence but may provide some benefits

Living with Mood Disorders: Coping Strategies

• Developing a strong support system of family, friends, and mental health professionals
• Educating oneself about the disorder and available treatment options
• Adhering to prescribed medication regimens and attending therapy sessions regularly
• Monitoring symptoms and triggers through journaling or mood tracking apps
• Practicing self-care activities (hobbies, relaxation techniques, physical exercise)
• Setting realistic goals and breaking them down into manageable steps
• Challenging negative thoughts and practicing positive self-talk
• Maintaining a structured daily routine and sleep schedule
• Avoiding alcohol and substance use, which can worsen symptoms and interact with medications
• Joining support groups or online communities to connect with others facing similar challenges

Hot Topics and Ongoing Research

• Exploring the role of inflammation and the immune system in the development of mood disorders
• Investigating the gut-brain axis and the influence of the microbiome on mental health
• Developing personalized medicine approaches based on genetic profiles and biomarkers
• Studying the long-term effects of childhood trauma and adversity on the risk of mood disorders
• Examining the efficacy of novel treatments, such as ketamine and psychedelic-assisted therapy
• Investigating the impact of social media and technology use on mood and mental well-being
• Addressing health disparities and improving access to mental health care for underserved populations
• Conducting large-scale longitudinal studies to better understand the course and outcomes of mood disorders