This refers to the significant reduction in the population of Native Americans post-European contact, primarily due to diseases brought by Europeans such as smallpox, measles, and influenza.
Epidemic: A widespread occurrence of an infectious disease in a community at a particular time.
Immunity: The ability of an organism to resist a particular infection or toxin by the action of specific antibodies or sensitized white blood cells.
Smallpox: An acute contagious viral disease, with fever and pustules usually leaving permanent scars. It was effectively eradicated through vaccination by 1979.
AP World History: Modern - 4.5 Maritime Empires Maintained and Developed
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